Morphology effect of bioglass-reinforced hydroxyapatite (Bonelike®) on osteoregeneration

摘要: In the last decades, well-known disadvantages of autografts and allografts have driven to development synthetic bone grafts for regeneration. Bonelike®, a glass-reinforced hydroxyapatite (HA) composite was developed registered grafting. This biomaterial is composed by modified HA matrix, with α- β-tricalcium phosphate secondary phases. Aiming improve biological characteristics new spherical pelleted granules, different shape size, were controlled micro macrostructure. present study, it compared physicochemical properties in vivo performance Bonelike® granule presentations—Bonelike® polygonal (500–1000 µm size) Bonelike (250–500 µm; 500–1000 size). For implanted on sheep femurs, various implantation times (30 days, 60 120 180 days). X-ray diffraction analysis revealed that phase composition granules presentations similar. most porous material (global porosity intraporosity) less porous. Considering both presented osteoconductive proprieties. The showed several advantages, including easier medical application through syringe improved osteointegration, osteoconduction, degradation, presence larger pores, micro- macrosctructure suitable particle format adapts growth. invasion throughout material's structure 250–500 appeared induce faster regeneration, presenting unfilled areas lacunae histological analysis. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 292–304, 2015.