Gene expression and activity of antioxidant enzymes in the blood cells of workers who were occupationally exposed to lead.
作者： Aleksandra Kasperczyk , Grzegorz Machnik , Michał Dobrakowski , Daniel Sypniewski , Ewa Birkner
DOI: 10.1016/J.TOX.2012.07.002
关键词:
摘要: Abstract In this study, we sought to understand the influence of occupational lead-exposure on gene expression (Sod1) and activity (SOD) superoxide dismutase, catalase glutathione peroxidase (GPx, Gpx1) in leukocytes erythrocytes. The study group consisted 45 healthy male employees a lead-zinc works was divided into two subgroups: those with low exposure lead (LE) high (HE). addition, 17 administrative workers participated as control group. levels both Sod1 Gpx1 were significantly increased LE compared By contrast, noted only an insignificant tendency for HE unchanged. Nevertheless, SOD GPx activities erythrocytes elevated examined subgroups, whereas raised results led us conclude that has significant not antioxidant enzymes but also dose-dependent their genes.
sci-hub.se 参考文章(48)
Kevin C. Staudinger, Victor S. Roth, Occupational lead poisoning. American Family Physician. ,vol. 57, pp. 719- 732 ,(1998)
Hugo Aebi, Catalase in vitro Methods in Enzymology. ,vol. 105, pp. 121- 126 ,(1984) , 10.1016/S0076-6879(84)05016-3
Z Yetkin-Ay, B Çadır, E Uskun, FY Bozkurt, N Delibaş, FM Gültepe, İ Ergürhan-İlhan, The periodontal status of indirectly lead-exposed apprentices working in autorepair workshops. Toxicology and Industrial Health. ,vol. 23, pp. 599- 606 ,(2007) , 10.1177/0748233708090906
Klaudia Jomova, Marian Valko, Advances in metal-induced oxidative stress and human disease Toxicology. ,vol. 283, pp. 65- 87 ,(2011) , 10.1016/J.TOX.2011.03.001
JosÉ M. MatÉs, Cristina Pérez-Gómez, Ignacio Núñez De Castro, Antioxidant enzymes and human diseases Clinical Biochemistry. ,vol. 32, pp. 595- 603 ,(1999) , 10.1016/S0009-9120(99)00075-2
Wei-Chiao Chang, Chen-Chia Chang, Yung-Song Wang, Yu-Shiuan Wang, Wei-Teng Weng, Tohru Yoshioka, Suh-Hang Hank Juo, Involvement of the epidermal growth factor receptor in Pb2+-induced activation of cPLA2/COX-2 genes and PGE2 production in vascular smooth muscle cells Toxicology. ,vol. 279, pp. 45- 53 ,(2011) , 10.1016/J.TOX.2010.09.004
Veena Sharma, Leena Kansal, Arti Sharma, Prophylactic Efficacy of Coriandrum sativum (Coriander) on Testis of Lead-Exposed Mice Biological Trace Element Research. ,vol. 136, pp. 337- 354 ,(2010) , 10.1007/S12011-009-8553-0
Jane Winer, Christopher Kwang S. Jung, Irene Shackel, P.Mickey Williams, Development and Validation of Real-Time Quantitative Reverse Transcriptase–Polymerase Chain Reaction for Monitoring Gene Expression in Cardiac Myocytesin Vitro Analytical Biochemistry. ,vol. 270, pp. 41- 49 ,(1999) , 10.1006/ABIO.1999.4085
H. M. Mousa, A. A. Al-Qarawi, B. H. Ali, H. A. Abdel Rahman, S. A. ElMougy, Effect of lead exposure on the erythrocytic antioxidant levels in goats. Journal of Veterinary Medicine Series A-physiology Pathology Clinical Medicine. ,vol. 49, pp. 531- 534 ,(2002) , 10.1046/J.1439-0442.2002.00499.X
Faruk �ktem, Meltem Koyuncu Arslan, Bumin D�ndar, Nam?k Delibas, Mustafa G�ltepe, Inci Erg�rhan Ilhan, Renal effects and erythrocyte oxidative stress in long-term low-level lead-exposed adolescent workers in auto repair workshops Archives of Toxicology. ,vol. 78, pp. 681- 687 ,(2004) , 10.1007/S00204-004-0597-5