Diacyl disulfides as the precursors for hydrogen persulfide (H2S2).

作者: Shi Xu , Yingying Wang , Zoel Parent , Ming Xian

DOI: 10.1016/J.BMCL.2019.126903

关键词:

摘要: Abstract While hydrogen polysulfides (H2Sn, n ≥ 2) are believed to play regulatory roles in biology, their fundamental chemistry and reactivity still poorly understood. Compounds that can produce H2Sn useful tools. In this work we found H2S2 could be effectively produced from diacyl disulfide precursors, triggered by certain nucleophiles, both aqueous solutions organic solvents. This method was used explore redox reactions of H2S2, such as scavenging 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) reduction tetrazines.

参考文章(31)
Shin Koike, Yuki Ogasawara, Norihiro Shibuya, Hideo Kimura, Kazuyuki Ishii, Polysulfide exerts a protective effect against cytotoxicity caused byt-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells FEBS Letters. ,vol. 587, pp. 3548- 3555 ,(2013) , 10.1016/J.FEBSLET.2013.09.013
John L. Wallace, Rui Wang, Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter Nature Reviews Drug Discovery. ,vol. 14, pp. 329- 345 ,(2015) , 10.1038/NRD4433
Frédéric Bouillaud, Céline Ransy, Serge Simonet, Christine Crespo, Marie-Pierre Bourguignon, Nicole Villeneuve, Jean-Paul Vilaine, Isabelle Artaud, Erwan Galardon, Thomas Roger, Francoise Raynaud, New biologically active hydrogen sulfide donors. ChemBioChem. ,vol. 14, pp. 2268- 2271 ,(2013) , 10.1002/CBIC.201300552
Csaba Szabó, Hydrogen sulphide and its therapeutic potential Nature Reviews Drug Discovery. ,vol. 6, pp. 917- 935 ,(2007) , 10.1038/NRD2425
MARSDEN S. BLOIS, Antioxidant Determinations by the Use of a Stable Free Radical Nature. ,vol. 181, pp. 1199- 1200 ,(1958) , 10.1038/1811199A0
Hideo KIMURA, Hydrogen sulfide and polysulfides as signaling molecules Nitric Oxide. ,vol. 91, pp. 131- 159 ,(2015) , 10.2183/PJAB.91.131
Melissa L. Blackman, Maksim Royzen, Joseph M. Fox, Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity. Journal of the American Chemical Society. ,vol. 130, pp. 13518- 13519 ,(2008) , 10.1021/JA8053805