Chemical analysis of DNA alterations
作者： Hans-Jürgen Rhaese , Ernst Freese
DOI: 10.1016/0005-2787(68)90193-7
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摘要: The chemical reactions between DNA and H2O2 or NH2OH, which at low concentration in the presence of oxygen produces H2O2, have been investigated using oligodeoxyadenylic acid. Both agents inactivate transforming cause an extensive decrease ultraviolet absorption melting temperature. In addition, they liberate all four bases from release both adenine altered base liberation is caused by oxidation C-1 carbon deoxyribose, producing deoxyribonic acid, has isolated characterized. Base acid formation, turn, results breakage sugar-phosphate backbone, as shown examination reaction products obtained Wherever it can occur, β-elimination preferred degradation reaction, whereas cyclization occurs when not possible.
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