Role of the peripheral innate immune system in the development of Alzheimer's disease.

摘要: Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact cause still not known although many scientists believe in beta amyloid hypothesis which states that accumulation peptide (Aβ) brain initial consequently leads to pathological neuroinflammation. However, it was recently shown Aβ may have an important role defending against infections. Thus, balance between positive and negative impact determine progression. Microglia are innate immune cells, brain-initiated inflammatory responses reflected periphery suggests some extent also a systemic disease. Greater permeability blood barrier facilitates transport peripheral cells vice versa so vicious circle originating on contribute development overt clinical AD. Persistent challenges by pathogens periphery, increasing with age, central propagation changes seen clinically. Therefore, activation status represent early biomarker upcoming brain. modulation these thus become useful mechanism for modifying