Rapamycin is a neuroprotective treatment for traumatic brain injury

摘要: The mammalian target of rapamycin, commonly known as mTOR, is a serine/threonine kinase that regulates translation and cell division. mTOR integrates input from multiple upstream signals, including growth factors nutrients to regulate protein synthesis. Inhibition leads cycle arrest, inhibition proliferation, immunosuppression induction autophagy. Autophagy, bulk degradation sub-cellular constituents, process keeps the balance between synthesis induced upon amino acids deprivation. Rapamycin, signaling inhibitor, mimics acid and, some extent, factor In present study we examined effect on outcome mice after brain injury. Our results demonstrate rapamycin injection 4 h following closed head injury significantly improved functional recovery manifested by changes in Neurological Severity Score, neurobehavioral testing. To verify activity injected demonstrated it inhibits p70S6K phosphorylation, reduces microglia/macrophages activation increases number surviving neurons at site We therefore suggest neuroprotective traumatic drug used clinic for other indications, propose further studies should be conducted order consider novel therapy