Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos

摘要: Background IgE is a key mediator of allergic inflammation, and its levels are frequently increased in patients with disorders. Objective We sought to identify genetic variants associated Latinos. Methods performed genome-wide association study admixture mapping total 3334 Latinos from the Genes-environments & Admixture Latino Americans (GALA II) study. Replication was evaluated 454 Latinos, 1564 European Americans, 3187 African independent studies. Results confirmed associations 6 genes identified by means previous studies novel significant polymorphism zinc finger protein 365 gene (ZNF365) (rs200076616, P  = 2.3 × 10 −8 ). next 4 peaks (6p21.32-p22.1, 13p22-31, 14q23.2, 22q13.1) at which local African, European, and/or Native American ancestry significantly levels. The most peak 6p21.32-p22.1, where lower ( 4.95 All but 22q13.1 were replicated an sample 2 (6p21.32-p22.1 14q23.2). Fine 6p21.32-p22.1 single nucleotide polymorphisms Americans. Another peak-wide within 14q23.2 (rs1741099, 3.7 −6 ) non–African samples .011). Conclusion ZNF365 , HLA-DQA1 14q23.2. Our results highlight importance studying diverse multiethnic populations uncover loci associated with