Morbidity and mortality in European children vertically infected by HIV-1. The French Pediatric HIV Infection Study Group and European Collaborative Study.

摘要: Based on 392 infected children enrolled in two European prospective studies of infants born to HIV-infected women, with similar standard protocols, HIV disease progression the first 6 years life is described, using 1994 CDC paediatric classification. Most had developed minor (A) or moderately severe (B) illness 4 life, although usually it was transient nature. Progression U.S. Centers for Disease Control and Prevention (CDC) group C HIV-related death an estimated 20% (95% confidence interval 16-24%) during year 4.7% (3.3-6.5%) per thereafter, giving a cumulative incidence 36% (30-43%) by years. The mortality rate at 26% (20-32%). Two thirds alive only symptoms, one third CD4+ cell distribution > 25% despite previous clinical manifestations period moderate immune deficiency. Differences zidovudine monotherapy between cohorts were not associated rate. However, risk bacterial infections lower French cohort, which use antibacterial prophylaxis more common. early, form affects approximately infants, after 75% are still alive. This has important implications health-care planning.