The effect of exercise on local and systemic adverse reactions after vaccinations – Outcomes of two randomized controlled trials

摘要: Abstract Introduction An adverse reaction associated with vaccination is considered to be a key barrier vaccinate, yet little attention has been given interventions reduce their occurrence. Exercise behavioural adjuvant which may also influence reactions. Here, two randomized controlled trials are reported, examining the effects of exercise on self-reported reactions following in adolescents and young adults. Methods Study one; 116 receiving HPV vaccine were randomly allocated either Control (n = 56) or Pre-vaccine (n = 60) group (2015–2016). consisted 15-minutes upper body exercise. two; 78 adults influenza (n = 19), one 3 groups: Arm Leg (n = 20) Post-vaccine (2017). included arm leg exercises prior after vaccination. All participants both studies completed an events diary for seven-days post-vaccination. Results Reported days tenderness female that exercised significantly lower than control (p = 0.032), similar trend reported pain (p = 0.050). Furthermore, feeling ill (p = 0.070) reduced appetite (p = 0.067) found exercise, although not significant. Overall, more (p = 0.003), (p  Discussion In separate trials, short bout vaccinations local systemic Gender differences evident among These findings support need further work examine potential benefit improving procedures.