What is a monophasic action potential

摘要: See article by Kondo et al. [6] (pages 635–644) in this issue . One approach to developing better pharmacologic therapy for arrhythmias is define the electrophysiologic mechanism clinical rhythm disturbances. However, problematic, because extracellular electrograms do not provide precise information regarding dispersion of repolarization or after-depolarizations. Floating microelectrodes have limitations an experimental laboratory and are widely applicable clinically. Thus, ability record monophasic action potentials (MAPs) using contact catheter electrodes both situations has raised hope that cellular properties important arrhythmogenesis can be identified reliably [1,2]. Indeed, several studies suggested arrhythmias, such as right ventricular outflow tract tachycardia, determined based on potential recordings [3,4]. there been some basic questions generation MAPs resolved, hampered fully interpret MAP recordings. The initial description was vivo electrode catheter, which a recording made between distal tip inactivates myocardium due pressure indifferent located milliliters … *Tel.: +1 312 926 0630; fax: 0607. Email address: a-kadish{at}northwestern.edu