Chitosan-alginate matrices loaded with leaf extracts of Anredera cordifolia Steenis as a gastrointestinal extended-release formulation
作者： Elsa Anisa Krisanti , Mutiara Primaster Wahyunisa , Nugrahirani Hijrianti , Kamarza Mulia
DOI: 10.1063/1.5139338
关键词:
摘要: The development of chitosan-alginate matrices loaded with Anredera cordifolia Steenis (Madeira-vine) leaf extract as an extended-release formulation is herewith described. Madeira-vine plants have been known used traditionally to treat various ailments such anti-inflammation, hypertension, and skin diseases. were prepared using the ionotropic gelation methodwith tripolyphosphate cross-linking agent. Scanning electron microscope Fourier transform infrared spectroscopy was investigate surface morphology structure matrices, respectively. effect alginate addition studied by determining physical characteristics encapsulation efficiency, loading capacity, matrix yield, well release profiles bioactive compounds in simulated gastrointestinal fluids. extracts quantified total phenolics, determined UV-spectrophotometry. High-performance liquid chromatography determine amount vitexin present extracts. efficiency phenolic at least 90%, highest capacity 1.23%, yield 83%. vitro assays showed a reduced cumulative synthetic gastric fluid (35 12%), and, three fluids (71 50%) after 24 hours, due chitosan matrix. These results indicate possibility employing matrixto shift phenolics from area colon area.The chromat...
harvard.edu
scitation.org
sci-hub.se 参考文章(27)
Fundamentals and applications of controlled release drug delivery Springer US. ,(2012) , 10.1007/978-1-4614-0881-9
Shih-Huang Yang, Pao-Hsin Liao, Ya-Fang Pan, Shiow-Ling Chen, Shih-Shen Chou, Ming-Yung Chou, The novel p53-dependent metastatic and apoptotic pathway induced by vitexin in human oral cancer OC2 cells. Phytotherapy Research. ,vol. 27, pp. 1154- 1161 ,(2013) , 10.1002/PTR.4841
Hyun-Ah Jung, Bao-Ning Su, William J. Keller, Rajendra G. Mehta, A. Douglas Kinghorn, Antioxidant Xanthones from the Pericarp of Garcinia mangostana (Mangosteen) Journal of Agricultural and Food Chemistry. ,vol. 54, pp. 2077- 2082 ,(2006) , 10.1021/JF052649Z
Sunil A. Agnihotri, Tejraj M. Aminabhavi, Controlled release of clozapine through chitosan microparticles prepared by a novel method. Journal of Controlled Release. ,vol. 96, pp. 245- 259 ,(2004) , 10.1016/J.JCONREL.2004.01.025
V.R Sinha, A.K Singla, S Wadhawan, R Kaushik, R Kumria, K Bansal, S Dhawan, Chitosan microspheres as a potential carrier for drugs International Journal of Pharmaceutics. ,vol. 274, pp. 1- 33 ,(2004) , 10.1016/J.IJPHARM.2003.12.026
C Remuñán-López, M.L Lorenzo-Lamosa, J.L Vila-Jato, M.J Alonso, Development of new chitosan–cellulose multicore microparticles for controlled drug delivery European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 45, pp. 49- 56 ,(1998) , 10.1016/S0939-6411(97)00122-7
Afrillia Nuryanti Garmana, Elin Yulinah Sukandar, Irda Fidrianny, Activity of Several Plant Extracts Against Drug-sensitive and Drug-resistant Microbes Procedia Chemistry. ,vol. 13, pp. 164- 169 ,(2014) , 10.1016/J.PROCHE.2014.12.021
Jin Wang, Yong-de Yue, Hao Jiang, Feng Tang, Rapid Screening for Flavone C-Glycosides in the Leaves of Different Species of Bamboo and Simultaneous Quantitation of Four Marker Compounds by HPLC-UV/DAD. International Journal of Analytical Chemistry. ,vol. 2012, pp. 205101- 205101 ,(2012) , 10.1155/2012/205101
Özgür Devrim Can, Ümide Demir Özkay, Umut İrfan Üçel, Anti-depressant-like effect of vitexin in BALB/c mice and evidence for the involvement of monoaminergic mechanisms. European Journal of Pharmacology. ,vol. 699, pp. 250- 257 ,(2013) , 10.1016/J.EJPHAR.2012.10.017