Lack of adaptive response to low doses of ionizing radiation in human lymphocytes from five different donors

摘要: Various investigators reported a reduced yield of chromosome and chromatid aberrations in short-term cultures human lymphocytes if 'challenge' exposure to ionizing radiation was preceded by an 'adaptive' exposure. In order examine the cell cycle dependence 'adaptive response', aberration yields were estimated after challenge doses G1, S or G2 phase which had been adapted early G1 phase. On testing two donors no protective adaptive response found. Blood samples four tested for their capability evoke standard experiment with dose A synergistic occurred one out similar experiments performed same blood sample. The three other did not respond. Apparently these data indicate high frequency lymphocyte that do display response.