Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors

Pier Paolo Sainaghi, Luigi Castello, Luca Bergamasco, Margherita Galletti, Paola Bellosta, Gian Carlo Avanzi, Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor. Journal of Cellular Physiology. ,vol. 204, pp. 36- 44 ,(2005) , 10.1002/JCP.20265

Christian Hartmann, Gesine Bartels, Claire Gehlhaar, Nikola Holtkamp, Andreas von Deimling, PIK3CA mutations in glioblastoma multiforme Acta Neuropathologica. ,vol. 109, pp. 639- 642 ,(2005) , 10.1007/S00401-005-1000-1

H. Tang, S. Chen, H. Wang, H. Wu, Q. Lu, D. Han, TAM receptors and the regulation of erythropoiesis in mice Haematologica. ,vol. 94, pp. 326- 334 ,(2009) , 10.3324/HAEMATOL.13635

Roy S. Herbst, Giuseppe Giaccone, Joan H. Schiller, Ronald B. Natale, Vincent Miller, Christian Manegold, Giorgio Scagliotti, Rafael Rosell, Ira Oliff, James A. Reeves, Michael K. Wolf, Annetta D. Krebs, Steven D. Averbuch, Judith S. Ochs, John Grous, Abderrahim Fandi, David H. Johnson, Gefitinib in Combination With Paclitaxel and Carboplatin in Advanced Non–Small-Cell Lung Cancer: A Phase III Trial—INTACT 2 Journal of Clinical Oncology. ,vol. 22, pp. 785- 794 ,(2004) , 10.1200/JCO.2004.07.215

Maria-Magdalena Georgescu, Kathrin H. Kirsch, Tomoyuki Shishido, Chen Zong, Hidesaburo Hanafusa, Biological Effects of c-Mer Receptor Tyrosine Kinase in Hematopoietic Cells Depend on the Grb2 Binding Site in the Receptor and Activation of NF-κB Molecular and Cellular Biology. ,vol. 19, pp. 1171- 1181 ,(1999) , 10.1128/MCB.19.2.1171

Li Liu, James Greger, Hong Shi, Yuan Liu, Joel Greshock, Roland Annan, Wendy Halsey, Ganesh M Sathe, Anne-Marie Martin, Tona M Gilmer, None, Novel Mechanism of Lapatinib Resistance in HER2-Positive Breast Tumor Cells: Activation of AXL Cancer Research. ,vol. 69, pp. 6871- 6878 ,(2009) , 10.1158/0008-5472.CAN-08-4490

Yardena Samuels, Zhenghe Wang, Alberto Bardelli, Natalie Silliman, Janine Ptak, Steve Szabo, Hai Yan, Adi Gazdar, Steven M Powell, Gregory J Riggins, James KV Willson, Sanford Markowitz, Kenneth W Kinzler, Bert Vogelstein, Victor E Velculescu, High Frequency of Mutations of the PIK3CA Gene in Human Cancers Science. ,vol. 304, pp. 554- 554 ,(2004) , 10.1126/SCIENCE.1096502

Tetsuya Mitsudomi, Satoshi Morita, Yasushi Yatabe, Shunichi Negoro, Isamu Okamoto, Junji Tsurutani, Takashi Seto, Miyako Satouchi, Hirohito Tada, Tomonori Hirashima, Kazuhiro Asami, Nobuyuki Katakami, Minoru Takada, Hiroshige Yoshioka, Kazuhiko Shibata, Shinzoh Kudoh, Eiji Shimizu, Hiroshi Saito, Shinichi Toyooka, Kazuhiko Nakagawa, Masahiro Fukuoka, Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial Lancet Oncology. ,vol. 11, pp. 121- 128 ,(2010) , 10.1016/S1470-2045(09)70364-X

Adil Anwar, Amy K. Keating, David Joung, Susan Sather, Grace K. Kim, Kelly K. Sawczyn, Luis Brandão, Peter M. Henson, Douglas K. Graham, Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress Journal of Leukocyte Biology. ,vol. 86, pp. 73- 79 ,(2009) , 10.1189/JLB.0608334

Sacha J. Holland, Mark J. Powell, Christian Franci, Emily W. Chan, Annabelle M. Friera, Robert E. Atchison, John McLaughlin, Susan E. Swift, Erlina S. Pali, George Yam, Stephen Wong, Joe Lasaga, Mary R. Shen, Simon Yu, Weiduan Xu, Yasumichi Hitoshi, Jakob Bogenberger, Jacques E. Nör, Donald G. Payan, James B. Lorens, Multiple Roles for the Receptor Tyrosine Kinase Axl in Tumor Formation Cancer Research. ,vol. 65, pp. 9294- 9303 ,(2005) , 10.1158/0008-5472.CAN-05-0993