Vaccines and immunotherapeutics comprising il-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same
作者： Kimberly A. Kraynyak , David B. Weiner , Michele Kutzler
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摘要: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with molecule encodes IL- 15Ra a functional fragment thereof are disclosed. Methods of inducing immune response individual against immunogen, using such compositions
lens.org参考文章(89)
J J Kim, L K Nottingham, J I Sin, A Tsai, L Morrison, J Oh, K Dang, Y Hu, K Kazahaya, M Bennett, T Dentchev, D M Wilson, A A Chalian, J D Boyer, M G Agadjanyan, D B Weiner, CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. Journal of Clinical Investigation. ,vol. 102, pp. 1112- 1124 ,(1998) , 10.1172/JCI3986
Dirk M. Anderson, Lisabeth Johnson, Moira B. Glaccum, Neal G. Copeland, Debra J. Gilbert, Nancy A. Jenkins, Virginia Valentine, Mark N. Kirstein, David N. Shapiro, Stephan W. Morris, Kenneth Grabstein, David Cosman, Chromosomal assignment and genomic structure of Il15 Genomics. ,vol. 25, pp. 701- 706 ,(1995) , 10.1016/0888-7543(95)80013-C
Ariane Plet, Catherine Harb, Erwan Mortier, Agnès Quemener, Yannick Jacques, Jérôme Bernard, Il-15 Binding Site for Il 15-Ralpha and Specific Il-15 Mutants Having Agonists/Antagonists Activity ,(2005)
Noriko Sato, Hiral J Patel, Thomas A Waldmann, Yutaka Tagaya, None, The IL-15/IL-15Rα on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 588- 593 ,(2007) , 10.1073/PNAS.0610115104
Dominick J. Laddy, Jian Yan, Michele Kutzler, Darwyn Kobasa, Gary P. Kobinger, Amir S. Khan, Jack Greenhouse, Niranjan Y. Sardesai, Ruxandra Draghia-Akli, David B. Weiner, Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens PLoS ONE. ,vol. 3, pp. e2517- ,(2008) , 10.1371/JOURNAL.PONE.0002517
Kholiswa C. Ngumbela, Kieran P. Ryan, Rohini Sivamurthy, Mark A. Brockman, Rajesh T. Gandhi, Nina Bhardwaj, Daniel G. Kavanagh, Quantitative effect of suboptimal codon usage on translational efficiency of mRNA encoding HIV-1 gag in intact T cells. PLOS ONE. ,vol. 3, ,(2008) , 10.1371/JOURNAL.PONE.0002356
Barbara K. Felber, George N. Pavlakis, John N. Vournakis, Sergio Finkielsztein, Complexes of il-15 and il-15ralpha and uses thereof ,(2008)
James P. Lodolce, Patrick R. Burkett, David L. Boone, Marcia Chien, Averil Ma, T Cell–Independent Interleukin 15rα Signals Are Required for Bystander Proliferation Journal of Experimental Medicine. ,vol. 194, pp. 1187- 1194 ,(2001) , 10.1084/JEM.194.8.1187
Daniel Scherman, Lluis Mir, Michel Bureau, Method for transferring nucleic acid into striated muscles ,(2001)
Sukhendu B. Dev, Gunter A. Hofmann, Nagendu B. Dev, Electrically induced vessel vasodilation ,(1999)