Strengths and weaknesses of in vitro assays for estrogenic and androgenic activity.
作者： Ana M. Soto , Maricel V. Maffini , Cheryl M. Schaeberle , Carlos Sonnenschein
DOI: 10.1016/J.BEEM.2005.09.001
关键词:
摘要: The endocrine and reproductive effects of xenobiotics are believed to be due (1) their mimicking the endogenous hormones; (2) antagonizing (3) altering pattern synthesis metabolism natural (4) modifying hormone receptor levels. It has been suggested that disruptors may play a role in decrease human semen quantity quality, an increase anomalies male genital tract, testicular breast cancer incidence during last 50 years. Testing these hypotheses will require: identifying estrogen androgen agonists antagonists among chemicals present environment; assessing interactions which humans exposed; finding markers (and androgen) exposure. development fast sensitive bioassays is central achievement three goals.
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