Rutin potentiates calcium uptake via voltage-dependent calcium channel associated with stimulation of glucose uptake in skeletal muscle.
作者： Virginia Demarchi Kappel , Leila Zanatta , Bárbara Graziela Postal , Fátima Regina Mena Barreto Silva
DOI: 10.1016/J.ABB.2013.01.008
关键词:
摘要: Rutin is a flavonoid with several pharmacological properties and it has been demonstrated that rutin can modulate glucose homeostasis. In skeletal muscle, an increase in intracellular calcium concentration may induce transporter-4 (GLUT-4) translocation consequent uptake. The aim of this study was to investigate the effect pathways on uptake as well involvement muscle. results show significantly stimulated through voltage-dependent channels mitogen-activated kinase (MEK) protein A (PKA) signaling pathways. Also, soleus muscle mediated by extracellular calcium-calmodulin-dependent II (CaMKII) activation. conclusion, stimulates rat muscles. Furthermore, involved DNA activation rutin. rutin-induced via CaMKII result GLUT-4 plasma membrane, characterizing insulin-independent pathway. These findings indicate potential drug candidate for diabetes therapy.
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