Efficient stepwise and one pot three-component synthesis of 2-amino-4-(2-oxo-2H-chromen-3-yl)thiophene-3-carbonitriles
作者： Devulapally Srikrishna , Pramod Kumar Dubey
DOI: 10.1016/J.TETLET.2014.10.021
关键词:
摘要: Environmentally benign conditions have been developed for the synthesis of 2-amino-4-(2-oxo-2H-chromen-3-yl)thiophene-3-carbonitriles (3) starting from 3-acetyl-2H-chromen-2-one (1) through intermediacy 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene)malononitrile (2) using Knoevenagel condensation followed by Gewald reaction. Alternatively, 3 could also be prepared in a one pot method treating equimolar amounts 1, malononitrile, and elemental sulfur. The merits this preparation are mild reaction conditions, easy work-up procedure, good yields.
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