Bispecific Aptamer Chimeras Enable Targeted Protein Degradation on Cell Membranes
作者： Da Han , Chao Zhang , Yang Yang , Yanyan Miao , Qianqian Gao
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摘要: The ability to regulate membrane protein abundance offers great opportunities for developing therapeutic sites for various diseases. Herein, we describe a platform for the targeted degradation of membrane‐associated proteins using bispecific aptamer chimeras that bind both the cell‐surface lysosome‐shuttling receptor (IGFIIR) and the targeted membrane‐bound proteins of interest. We demonstrate that the aptamer chimeras can efficiently and quickly shuttle the therapeutically relevant membrane proteins of Met and PTK …
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