Dietary nucleotide supplementation reduces occurrence of diarrhoea in early weaned pigs

摘要: Abstract In the weaning period, transition from sow's milk to post-weaning diet causes withdrawal of important nutrients as nucleotides, which are known be determinant for development gastrointestinal tract and immune function. The objective these investigations was study effect including nucleotides in solid diets piglets. Nucleotide composition analyzed using 5 sows at 21 days lactation. average free nucleotide concentration 102.8 ± 9.16 μmol/100 mL. Two experiments were performed assess a product based on this (Nucleoforce Piglets®) digestive adaptation incidence diarrhoea nursery Exp. 1, three groups 6 piglets weaned age fed with supplemented 0 (control), 1000 or 2000 ppm fourth group maintained Seven days after weaning, euthanized samples jejunal mucosa processed histological measurements. Villus height decreased 448 μm un-weaned pigs 275 μm control 7 days weaning. Although there no differences feed intake among groups, reduction villous less pronounced (P