Considerations and caveats in anti-virulence drug development.
作者： Damien Maura , Alicia E Ballok , Laurence G Rahme
DOI: 10.1016/J.MIB.2016.06.001
关键词:
摘要: As antibiotic resistance remains a major public health threat, anti-virulence therapy research is gaining interest. Hundreds of potential compounds have been examined, but very few made it to clinical trials and none approved. This review surveys the current field with focus on highly resistant deadly ESKAPE pathogens, especially Pseudomonas aeruginosa. We discuss timely considerations caveats in drug development, including target identification, administration, preclinical metrics for success trials. Development defined pipeline agents, which differs important ways from conventional antibiotics, imperative future these critically needed drugs.
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