Mammalian Cloning: Challenges for the Future

摘要: Publisher Summary Although the number of laboratories working on mammalian reproductive cloning has increased dramatically in past few years, proportion eggs or zygotes with a genome that been transferred from another cell remains obstinately at percent. most attrition occurs around time implantation, late-gestation and early-postpartum deaths, regardless species, are more prevalent clones. An optimistic view would be this is simply because limitations existing techniques once these concerns have addressed, higher success rates will achieved routinely. Unlike other not an option for critically testing effectiveness reprogrammed donor nuclei humans. Hence, realizing therapeutic humans, important outstanding issue how to ensure differentiated progeny embryonic stem (ES) cells derived way safe treating patients. In persisting uncertainties concerns, opinion within biomedical research community divided as whether offer viable approach circumventing rejection harnessing ES tissue repair. The widespread present support moratorium human cloning, both scientific outside it, rooted two types concerns. Ethical considerations dominant community, whereas about safety featured prominently debate community. There opposing views worries warranted.