Microwave Promoted and Improved Thermal Synthesis of Spiro[Indole‐Pyranobenzopyrans] and Spiro[Indole‐Pyranoimidazoles]
作者： Anshu Dandia , Ruby Singh , Harshita Sachdeva , Rajive Gupta , Satya Paul
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摘要: Spiro[indole-pyranoimidazoles] (5) and spiro[indole-pyranobenzopyrans] (6) are readily synthesized in one step 86–92 91–97% yields by the Michael condensation of 3-dicyanomethylene-2H-indol-2-ones (2) with 1-phenyl-2-thiohydantoin (3) 4-hydroxy-2H-1-benzopyran-2-one (4), respectively, without using any catalyst under different reaction conditions (conventional heating microwave irradiation (a) polar solvents (b) neutral alumina/silica gel as inorganic solid support solvent free conditions). 2 was situ Knoevenagel indole-2,3-dione (1) malononitrile absence catalyst. 100% conversion observed most cases on TLC which also showed formation a single product. The comparison between various methods is established.
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