Identification of autoantibodies specific for the neutrophil adhesion glycoproteins CD11b/CD18 in patients with autoimmune neutropenia

摘要: NTI-NEUTROPHIL antibodies may be detected in A various conditions associated with neutropenia, including rheumatoid arthritis, systemic lupus erythematosus, chronic active hepatitis, human immunodeficiency virus (HIV) disease, and drug reactions.’-4 Anti-neutrophil also present the sera of adults children neutropenia not other disorders. Titers anti-neutrophil occasionally have been correlated severity implying an etiologic role for these ne~tropenia.~.’ To date, there has limited information regarding antigenic specificities naturally occurring antineutrophil autoantibodies. Certain neutrophil antigens classified using serologic techniques based on vitro agglutination assays? recently relationships between some recognized by known surface glycoproteins (GPs) established. The NA1 NA2 identified as glycosylated isoforms Fc y receptor 111,1”2 NB1 antigen shown to reside a 58- 64-Kd GP neutrophils secondary gran~1es.I~ In addition, we demonstrated that specific actin are patients autoim