BDNF Val66Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: a pilot study

摘要: Brain-derived neurotrophic factor (BDNF) Val66Met genotype has been associated with neurobehavioral deficits. To examine its relevance for addiction, we examined BDNF differences in drug-seeking behavior. Heroin-dependent volunteers (n = 128) completed an interview that assessed past-month naturalistic drug-seeking/use behaviors. In African Americans (n = 74), the Met allele was uncommon (carrier frequency 6.8%); thus, analyses focused on European (n = 54), whom common 37.0%). their natural setting, carriers (n = 20) reported more time- and cost-intensive heroin-seeking cigarette use than Val homozygotes (n = 34). predicted 18.4% of variance ‘weekly heroin investment’ (purchasing time × amount × frequency). These data suggest may confer a ‘preferred drug-invested’ phenotype, resistant to moderating effects higher drug prices non-drug reinforcement. preliminary hypothesis-generating findings require replication, but are consistent pre-clinical demonstrate influence Whether this is relevant other abused substances besides opioids or nicotine, treatment response, remains be determined.