Clinical applications of stereotactic radiosurgery

摘要: Stereotactic radiosurgery was a radical departure from the general approach to clinical radiotherapy and radiobiology during decades of 1950s through 1980s. The prevailing trends at time were increasing fractionation (eventually moving testing hyperfractionation for many tumors), treatment larger fields (such as whole CNS axis irradiation germinoma, ependymoma, medulloblastoma), avoiding benign diseases prevent causing radiation-induced neoplasms. Radiosurgery defined in 1951 single-session, closed-skull destruction stereotactically intracranial target with high-dose ionizing external beam [1]. What started out seemingly heretical technique on fringes radiation oncology neurosurgery is now firmly established, widely used technique, over 14,000 patients treated per year worldwide Gamma Knife sites alone.