Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1

摘要: Abstract Apicomplexan parasites are obligate intracellular pathogens that cause a host of human and animal diseases. These have developed universal mechanism invasion involving formation ‘moving junction’ provides stable anchoring point through which the parasite invades cells. The composition moving junction, particularly presence protein Apical Membrane Antigen 1 (AMA1), has recently been subject some controversy. In this commentary we review findings led to current model junction complex dissect major conflicts determine whether substantial reassessment role AMA1 is justified.