Neurofilament Transport in Axonal Regeneration

摘要: Regenerating axons have been intensively studied with regard to the mechanisms and determinants of elongation, several lines evidence suggest that delivery cytoskeletal proteins (tubulin actin, in particular) are correlates outgrowth may be rate limiting (see Lasek Hoffman, 1976; Wujck Lasek. 1983). In addition lo changes axonal length, regeneration involves marked caliber composition. The rcgcneraling axon provides best available system which test critically hypotheses underlying our recent studies. These neurofilament content is major correlate is, turn, determined, large part, by via slow transport. This review will first summarize general problem then focus on data from regenerating nerves. can considered terms three regions axon—the proximal stump, maturing sprouts, distal sprouts.