The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer.

摘要: Prostate cancer is the second most common in men, for which there are no reliable biomarkers or targeted therapies. Here we demonstrate that elevated levels of Δ133TP53β isoform characterize prostate cancers with immune cell infiltration, particularly T cells and CD163+ macrophages. These associated shorter progression-free survival, Gleason scores ≥ 7, an immunosuppressive environment defined by a higher proportion PD-1, PD-L1 colony-stimulating factor 1 receptor (CSF1R) positive cells. Consistent this, RNA-seq tumours showed enrichment pathways signalling migration. We further show role hypoxia wild-type p53 upregulating Δ133TP53 levels. Finally, AUC analysis expression level alone predicted aggressive disease 88% accuracy. Our data identify as highly accurate prognostic cancer.