Association of γ‐glutamyl transferase (GGT) activity with treatment and clinical outcomes in chronic hepatitis C (HCV)

摘要: Increased γ-glutamyl transferase (GGT) activity is associated with liver injury and mortality in the general population. Less known about its association chronic hepatitis C (HCV) outcomes. We examined GGT as a predictor of both virological response to treatment long-term clinical outcomes Hepatitis Anti-viral Treatment Against Cirrhosis Trial (HALT-C). HALT-C enrolled patients advanced disease (Ishak fibrosis score ≥3) two phases: lead-in establish lack sustained viral full dose pegylated interferon (IFN) ribavirin followed by 3.5-year randomized trial low-dose IFN. Low-dose IFN did not prevent progression, were then for up an additional 5 years off therapy. Analyses performed 1,319 who had measured prior initiation treatment. Increases risk each increase quintile (10-57, 58-89, 90-139, 140-230, 231-2,000 IU/L) determined logistic regression or Cox Baseline was male sex, nonwhite ethnicity, diabetes insulin resistance, interleukin (IL)28B rs12979860 CT TT genotypes, numerous markers severity. In phase, increasing strongly diminished week 20 response, end univariate multivariate analyses controlling factors be (P < 0.0001). also all analysis 0.05) except hepatocellular carcinoma = 0.46 analysis). Conclusion: independent among due HCV. (HEPATOLOGY 2013)