Tetrodotoxin and manganese ions: effects on electrical activity and tension in taenia coli of guinea pig
作者： Y. Nonomura , Y. Hotta , H. Ohashi
DOI: 10.1126/SCIENCE.152.3718.97
关键词:
摘要: Tetrodotoxin, at concentrations up to 5 x 10(-6) gram per milliliter, has no effect on the spontaneous discharge in smooth muscle of taenia coli. However, is abolished by Mn(++) a concentration 0.5 millimole liter. The contraction induced immersing isotonic KCl solution also suppressed presence Mn(++). Because specific suppressor spike Ca(++) and tetrodotoxin an inhibitor Na(+), we suggest that charge carrier production potential entry intervening through membrane acts as trigger for muscle.
sciencemag.org
harvard.edu参考文章(10)
S. Hagiwara, S. Nakajima, Tetrodotoxin and Manganese Ion: Effects on Action Potential of the Frog Heart Science. ,vol. 149, pp. 1254- 1255 ,(1965) , 10.1126/SCIENCE.149.3689.1254
NORIKO YUKISADA, FUMIKO EBASHI, ROLE OF CALCIUM IN DRUG ACTION ON SMOOTH MUSCLE Japanese Journal of Pharmacology. ,vol. 11, pp. 46- 53 ,(1961) , 10.1254/JJP.11.46
D. H. L. EVANS, H. O. SCHILD, Mechanism of contraction of smooth muscle by drugs. Nature. ,vol. 180, pp. 341- 342 ,(1957) , 10.1038/180341C0
Toshio Narahashi, John W. Moore, William R. Scott, Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant Axons The Journal of General Physiology. ,vol. 47, pp. 965- 974 ,(1964) , 10.1085/JGP.47.5.965
EDITH BÜLBRING, G. BURNSTOCK, Membrane potential changes associated with tachyphylaxis and potentiation of the response to stimulating drugs in smooth muscle British journal of pharmacology and chemotherapy. ,vol. 15, pp. 611- 624 ,(1960) , 10.1111/J.1476-5381.1960.TB00289.X
Susumu Hagiwara, Ken-ichi Naka, THE INITIATION OF SPIKE POTENTIAL IN BARNACLE MUSCLE FIBERS UNDER LOW INTRACELLULAR CA The Journal of General Physiology. ,vol. 48, pp. 141- 162 ,(1964) , 10.1085/JGP.48.1.141
Edith Bülbring, H. Kuriyama, Effects of changes in the external sodium and calcium concentrations on spontaneous electrical activity in smooth muscle of guinea-pig taenia coli The Journal of Physiology. ,vol. 166, pp. 29- 58 ,(1963) , 10.1113/JPHYSIOL.1963.SP007089
P. Fatt, B. L. Ginsborg, The ionic requirements for the production of action potentials in crustacean muscle fibres The Journal of Physiology. ,vol. 142, pp. 516- 543 ,(1958) , 10.1113/JPHYSIOL.1958.SP006034
Mollie E. Holman, Membrane potentials recorded with high-resistance micro-electrodes; and the effects of changes in ionic environment on the electrical and mechanical activity of the smooth muscle of the taenia coli of the guinea-pig The Journal of Physiology. ,vol. 141, pp. 464- 488 ,(1958) , 10.1113/JPHYSIOL.1958.SP005989
R. K. Orkand, Chemical inhibition of contraction in directly stimulated crayfish muscle fibres The Journal of Physiology. ,vol. 164, pp. 103- 115 ,(1962) , 10.1113/JPHYSIOL.1962.SP007005