Origin and development of neuropil glia of the Drosophila larval and adult brain: Two distinct glial populations derived from separate progenitors.

摘要: Glia comprise a conspicuous population of non-neuronal cells in vertebrate and invertebrate nervous systems. Drosophila serves as favorable model to elucidate basic principles glial biology vivo. The neuropil glia (NPG), subdivided into astrocyte-like (ALG) ensheathing (EG), extend reticular processes which associate with synapses sheath-like surround compartments, respectively. In this paper we characterize the development NPG throughout fly brain development. We find that differentiated larval originate cluster precursors derived from embryonic progenitors located basal brain. These undergo characteristic migration spread over surface while specifying/differentiating primary ALG EG. Embryonically-derived are large few number, occupy relatively stereotyped positions around surface. During metamorphosis, cell death. Neuropil adult (secondary NPG) type II lineages during postembryonic phase neurogliogenesis. secondary much smaller size but greater number than NPG. Lineage tracing reveals both subtypes derive intermediate neural multipotent lineages. Taken together, study previously uncharacterized dynamics provides framework for future studies utilizing model.