Improving acute demyelinating lesion detection: which T1-weighted magnetic resonance acquisition is more sensitive to gadolinium enhancement?

摘要: Objective Because of the need for a standardized and accurate method detecting multiple sclerosis (MS) inflammatory activity, different magnetic resonance (MR) acquisitions should be compared in order to choose most sensitive sequence clinical routine. To compare sensitivity T1-weighted image single dose gadolinium (Gd) administration both with without magnetization transfer detect contrast enhancement active demyelinating focal lesions. Methods A sample relapsing-remitting MS patients were prospectively examined separately by two neuroradiologists using 1.5 Tesla scanner. The outcome parameters focused on Gd-enhancement detection attributed acute demyelination. All MR examinations at least one Gd-enhancing lesion considered positive (MR+) each was analyzed according its size ratio. Results Thirty-six high inter-observer agreement MR+ (k coefficient > 0.8), which excellent number lesions (0.91 T1 spin-echo (SE), 0.88 (MTC) 0.99 magnetization-prepared rapid acquisition gradient-echo (MPRAGE). Significantly more reported MTC scans, followed SE, MPRAGE scans. Confidently, demonstrated higher accuracy lesions, SE sequences. Further comparisons showed that there statistically significant increase ratio area images when images. Conclusion Single-dose Gd confirmed predicting T magnet this patients.