Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease.
作者： Ute Günther , Adrian C Bateman , R Mark Beattie , Michael Bauer , Thomas T MacDonald
DOI: 10.1111/J.1365-2559.2010.03652.X
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摘要: Gunther U, Bateman A C, Beattie R M, Bauer MacDonald T & Kaskas B (2010) Histopathology 57, 427–435 Connective tissue growth factor expression is increased in collagenous colitis and coeliac disease Aims: Subepithelial collagen deposition a classical feature of (CC), but also seen untreated disease. The end-stage mediator excess cellular production connective (CTGF). aim this study was to investigate CTGF by situ hybridization (ISH) polymerase chain reaction (PCR) CC disease as well lymphocytic (LC), Crohn’s ulcerative (UC). Methods results: For we analysed fresh frozen material quantitative reverse transcription–polymerase (RT–PCR) archival for ISH. PCR transcripts were moderately elevated labelled cells significantly the subepithelial zone. CC, LC UC investigated because rarity first two conditions. There marked increase zone localizing with morphology smooth muscle cells, which not LC. Conclusions: colocalization areas excessive suggest that it might be local fibrosis these
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