Toxicological considerations for intravitreal drugs.
作者： Fernando M Penha , Eduardo B Rodrigues , Bruno A Furlani , Eduardo Dib , Gustavo B Melo
DOI: 10.1517/17425255.2011.585970
关键词:
摘要: Introduction: Intravitreal injections are a very common procedure and the most effective route of drug delivery to retina. There currently several drugs available even more in development; therefore, safety is important concern. Areas covered: The toxicological considerations used for intravitreal pharmacotherapy such as anti-VEGFs, corticosteroids antibiotics. Emerging agents anti-TNFs, VEGF-trap kinase inhibitors also discussed. An assessment efficacy issues relevant including bevacizumab, ranibizumab triamcinolone presented. Expert opinion: toxicology profiles that either use or will be injections. Retinal different retinal diseases; however issue when applied possibility toxicity should always ke...
core.ac.uk
sci-hub.se 参考文章(101)
Verteporfin therapy of subfoveal minimally classic choroidal neovascularization in age-related macular degeneration: 2-year results of a randomized clinical trial. Archives of Ophthalmology. ,vol. 123, pp. 448- 457 ,(2005) , 10.1001/ARCHOPHT.123.4.448
E Zemel, M Lazar, A Loewenstein, I Perlman, The effects of Depo-Medrol preservative on the rabbit visual system. Investigative Ophthalmology & Visual Science. ,vol. 32, pp. 3053- 3060 ,(1991)
Glenn J. Jaffe, Chang Hao Yang, John P. Denny, Hong Guo, Paul Ashton, Cristiana Lima, Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 3569- 3575 ,(2000)
Yamashita Y, Komatsu K, Mochizuki K, Torisaki T, Tanahashi T, Sakai H, Intraocular penetration and effect on the retina of fluconazole. Lens and eye toxicity research. ,vol. 9, pp. 537- ,(1992)
J Fernando Arevalo, Rafael A Garcia-Amaris, Jose A Roca, Juan G Sanchez, Lihteh Wu, Maria H Berrocal, Mauricio Maia, Pan-American Collaborative Retina Study Group, Primary intravitreal bevacizumab for the management of pseudophakic cystoid macular edema: pilot study of the Pan-American Collaborative Retina Study Group. Journal of Cataract and Refractive Surgery. ,vol. 33, pp. 2098- 2105 ,(2007) , 10.1016/J.JCRS.2007.07.046
M. M. McLaughlin, L. Ye, B. March, T. Hunt, A. Bayliffe, R. Brigandi, P. Lebowitz, C. Bailey, B. Suttle, R. Danis, A Multi-Targeted Receptor Tyrosine Kinase Inhibitor for the Treatment of Neovascular AMD: Results of a Healthy Volunteer Safety and Tolerability Study of Pazopanib Eye Drops Investigative Ophthalmology & Visual Science. ,vol. 50, pp. 5008- 5008 ,(2009)
Daniel F Martin, Maureen G Maguire, GSet al Ying, Juan E Grunwald, Stuart L Fine, Glenn J Jaffe, None, Ranibizumab and bevacizumab for neovascular age-related macular degeneration. The New England Journal of Medicine. ,vol. 364, pp. 1897- 1908 ,(2011) , 10.1056/NEJMOA1102673
Aimee V Chappelow, Peter K Kaiser, Neovascular Age-Related Macular Degeneration: Potential Therapies Drugs. ,vol. 68, pp. 1029- 1036 ,(2008) , 10.2165/00003495-200868080-00002
Demetrios Vavvas, Donald J. D'Amico, Pegaptanib (Macugen): treating neovascular age-related macular degeneration and current role in clinical practice. Ophthalmology Clinics of North America. ,vol. 19, pp. 353- 360 ,(2006) , 10.1016/J.OHC.2006.05.008
C.K. Chan, S.G. Lin, Retinal Pigment Epithelial Tear after Ranibizumab Therapy for Subfoveal Fibrovascular Pigment Epithelial Detachment European Journal of Ophthalmology. ,vol. 17, pp. 674- 676 ,(2007) , 10.1177/112067210701700432