Overexpression of HPV16 E6/E7 mediated HIF-1α upregulation of GLUT1 expression in lung cancer cells

摘要: High-risk human papillomavirus (HPV) infection may play an important role in non-small cell lung carcinoma (NSCLC) development. However, some recent studies have proved that it was not directly associated with cancer. The aim of this study to evaluate the underlying molecular mechanism HPV16 regulate expression GLUT1 and promote development HPV16, HIF-1α, were detected pleural effusions patients cancer (n = 95) benign disease (n = 55) by immunocytochemistry. Western blotting qRT-PCR used detect chances E6/E7, cells. significantly more likely be expressed malignant group than as immunocytochemistry (ICC), HIF-1α correlated or (P < 0.01). Expression changes E6 E7 promoted protein both mRNA GLUT1, but had no effect on After inhibition obviously downregulated regulated due mediation These results suggest regulation Warburg a valuable therapeutic target for HPV-related