C-Met in invasive breast cancer: is there a relationship with the basal-like subtype?

摘要: BACKGROUND Basal-like (BL) breast cancer is an aggressive form of with limited treatment options. Recent work has identified BL as a biologically distinct triple-negative cancer, worse outlook. The receptor tyrosine kinase c-Met novel therapeutic target associated reduced survival in cancer. Few studies have specifically addressed the association between and molecular subtype yet this key consideration when selecting patients for clinical trials. aim study to evaluate expression large cohort invasive cancers particular, its correlation subtype. METHODS Immunohistochemistry was performed evaluated on 1274 using tissue microarray technology. scores were correlated subtype, survival, other standard clinicopathological prognostic factors. RESULTS Multivariate logistic regression showed independently status (odds ratio = 6.44, 95% confidence interval = 1.74-23.78, P = .005). There positive Her2 (P = .005) inverse tumor size (P < .001). C-Met independent poor factor at Cox analysis all subtypes (hazard ratio = 1.85, interval = 1.07-3.19, P = .027) there trend toward tumors overexpressing c-Met, but not significant. CONCLUSIONS C-Met In future, should be included trials anti-c-Met therapy. Cancer 2014;120:163–171. © 2013 American Society.