Effects of Acute Smoked Marijuana on Complex Cognitive Performance

摘要: Although the ability to perform complex cognitive operations is assumed be impaired following acute marijuana smoking, performance after use has not been adequately assessed under experimental conditions. In present study, we used a within-participant double-blind design evaluate effects smoking on in experienced smokers. Eighteen healthy research volunteers (8 females, 10 males), averaging 24 cigarettes per week, completed this three-session outpatient study; sessions were separated by at least 72-hrs. During sessions, participants baseline computerized tasks, smoked single cigarette (0%, 1.8%, or 3.9% Δ9-THC w/w), and additional tasks. Blood pressure, heart rate, subjective also throughout sessions. Marijuana administered fashion sequence of concentration order was balanced across participants. significantly increased number premature responses time required complete several it had no effect accuracy measures flexibility, mental calculation, reasoning. Additionally, rate subjective-effect ratings (e.g., “Good Drug Effect,” “High,” “Mellow”) concentration-dependent manner. These data demonstrate that produced minimal task users.