Hypha formation in the white-opaque transition of Candida albicans.

摘要: Cells of Candida albicans strain WO-1 and related strains switch frequently reversibly between a white-colony-forming unit (white phase) gray-colony-forming (opaque phase). in the budding white phase exhibit usual smooth round phenotype observed other C. strains, but cells opaque unique elongate shape with surface pimples or protrusions. In this study, it was demonstrated that formed hyphae at low to negligible levels suspension cultures could be induced form high when anchored chamber wall perfusion monolayer human skin epithelial cells. Variability proportion experiments appeared due variability individual clones. The by were morphologically identical (i.e., they devoid protrusions exhibited same septal locations). They also did not stain an opaque-specific antiserum which differentially stained punctate fashion. However, stimulated buds, opaque-shaped daughter demonstrating although are similar cells, genetically opaque. Images