Molecular assessment of disease states in kidney transplant biopsy samples

摘要: Progress in renal transplantation requires improved understanding and assessment of rejection injury. Study the relationship between gene expression clinical phenotypes kidney transplant biopsy samples has led to development a system that enables diagnoses specific disease states on basis messenger RNA levels sample. Using this we have defined molecular landscape T cell-mediated (TCMR), antibody-mediated (ABMR), acute injury (AKI), tubular atrophy interstitial fibrosis. TCMR ABMR share IFNγ-mediated effects emerged as cognate cell-antigen presenting cell process interstitium, whereas is natural-killer-cell-mediated occurs microcirculation. The features these different processes creation classifiers test for ABMR, revealed principal cause deterioration. changes associated with are often more extensive than suggested by histology indicate progression graft failure caused continuing nephron injury, rather fibrogenesis. In summary, advances involved outcomes.