Association between F+1 polymorphism in a disintegrin and metalloprotease 33 (ADAM33) gene and chronic obstructive pulmonary disease susceptibility: An evidence-based meta-analysis

摘要: Abstract Background The F+1 (rs511898 G>A) polymorphism in a disintegrin and metalloprotease 33 (ADAM33) gene has been implicated susceptibility of chronic obstruction pulmonary disease (COPD). However, series studies have reported inconclusive. aim this study is to explore the association between (rs511898) ADAM33 COPD by using method meta-analysis. Method PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure database (CNKI), Chongqing VIP database, Wanfang China Biology Medicine (CBM) were searched comprehensively obtain related cohort case-control studies. included selected according inclusion criteria. pooled odds ratios performed respectively for allele comparison, additive model, dominant genetic model recessive model. was measured OR 95%CI STATA 12.0. subgroup analysis distinguished ethnicity. publication bias tested funnel plots Egger's linear regression method. Results Twelve meta-analysis, which comprised 6935 participants (2454 patients with 4481 controls). meta results showed significant total = 1.16(95% CI 1.04–1.30, P = 0.007), Asian = 1.14(95% 1.02–1.27, P = 0.022), total = 1.27 (95% 1.13–1.43, P = 0.000), Asian = 1.25 1.08–1.45, P = 0.003), total = 1.49 1.16–1.91, P = 0.002), Asian = 1.56(95% 1.09–2.22, P = 0.014), but not Caucasians. Conclusion mutant A may increase risk among Asian population, while it associate European population.