A single dose of doxycycline in combination with diethylcarbamazine for treatment of bancroftian filariasis.
作者： Vivornpun Sanprasert , Surang Nuchprayoon , Anupong Sujariyakul
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摘要: Standard treatment of lymphatic filariasis with diethylcarbamazine (DEC) is associated systemic adverse reactions, thought to be due the release microfilariae material and Wolbachia endosymbiotic bacteria into blood. Combination treatments doxycycline for 3-8 weeks are more effective than standard treatment. However, long-term use antibiotics may contribute drug resistance not practical in remote areas. We assessed whether a single dose combined DEC regimen would reduce incidence severity reactions increase efficacy Forty-four subjects from Tak Province were recruited randomized double-blind clinical trial study: 25 received (300 mg) placebo, 19 (200 mg). The incidences lower group (45.5%) placebo (58.8%). Severe occurred only (3 subjects). was significantly (mean score 0.45) 1.17). levels IL-6 DNA plasma group. filarial antigen at months 6 after
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