Selective Systems in Somatic Cell Genetics

摘要: Experimental mutagenesis, cell hybridization, and intercellular gene transfer appear to be the three most significant technical developments in recent years that have stimulated rapid advances somatic genetics. The ability induce mutations animal plant cells culture enriches genetic variability of populations for further biochemical analysis. process mutagenesis mutation rates high eukaryotic can thus studied compared with those known prokaryotes. success fusion between diverse parental genomes into multinucleate heterokaryons or synkaryonic hybrids has also led a variety investigative possibilities, among which are studies genomic interactions expression, complementation, recombination, segregation, mapping genes. However, parasexual material from one another is not limited intact cells. Successful attempts been reported isolated DNA, chromosomes, nuclear fragments introduced living mammalian expression heterologous gene(s) recipient transmission “acquired” character (s) progeny problems fundamental interest significance.