Investigation of the Cause of Precocious Puberty in an 8-Year-Old Girl Ended up in Juvenile Granulosa and Theca Cell Tumor of the Ovary

摘要: Isosexual precocious puberty in girls has several etiologies. Juvenile granulose cell tumor is one of the rarest causes that only stands for 1.5% ovarian cancers. This mostly encounters first 2 decades life. paper a report an 8-year-old girl with within five months developed breast enlargement followed by menarche. Works which are done to find underlying cause revealed juvenile granulosa her left ovary. She then under went laparoscopic surgery and 3 courses chemotherapy. did not experience any vaginal bleeding after serum level estradiol lay among its normal ranges, but relapsed presented as abdominal pain huge mass resection all afflicted tissues. After chemotherapy, status deteriorated unfortunately she died 6 from time diagnosis. Treatment this disease consists If diagnosed early stages, it will be curable, advanced up 80% patients die recurrent tumors. The reported patient was at stage IIIC had poor prognosis.