Emotional eating is associated with increased brain responses to food-cues and reduced sensitivity to GLP-1 receptor activation

作者: Madeleine L. Drent , Frederik Barkhof , Michaela Diamant , Richard G. IJzerman , Liselotte van Bloemendaal

DOI: 10.1002/OBY.21200

关键词:

摘要: Objective The neural correlates and pathophysiology of emotional eating are insufficiently known. Glucagon‐like peptide‐1 (GLP‐1), a postprandial hormone, plays a role in feeding behavior by signaling satiety to the brain. GLP‐1 receptor agonists, used for treatment of type 2 diabetes (T2DM), promote weight loss. This study investigated the association between emotional eating and responses to food‐cues in brain areas involved in satiety and reward processing, as well as GLP‐1 receptor agonist‐induced effects on these brain …

参考文章(40)
Michael W. Schwartz, Stephen C. Woods, Daniel Porte, Randy J. Seeley, Denis G. Baskin, Central nervous system control of food intake Nature. ,vol. 404, pp. 661- 671 ,(2000) , 10.1038/35007534
T. A. Hare, J. O'Doherty, C. F. Camerer, W. Schultz, A. Rangel, Dissociating the Role of the Orbitofrontal Cortex and the Striatum in the Computation of Goal Values and Prediction Errors The Journal of Neuroscience. ,vol. 28, pp. 5623- 5630 ,(2008) , 10.1523/JNEUROSCI.1309-08.2008
Yvonne Rothemund, Claudia Preuschhof, Georg Bohner, Hans-Christian Bauknecht, Randolf Klingebiel, Herta Flor, Burghard F. Klapp, Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals NeuroImage. ,vol. 37, pp. 410- 421 ,(2007) , 10.1016/J.NEUROIMAGE.2007.05.008
DAVID M. GARNER, MARION P. OLMSTED, Scoring the Eating Disorder Inventory American Journal of Psychiatry. ,vol. 143, pp. 680- 681 ,(1986) , 10.1176/AJP.143.5.680-A
Donna L. Murdaugh, James E. Cox, Edwin W. Cook, Rosalyn E. Weller, fMRI reactivity to high-calorie food pictures predicts short- and long-term outcome in a weight-loss program. NeuroImage. ,vol. 59, pp. 2709- 2721 ,(2012) , 10.1016/J.NEUROIMAGE.2011.10.071
Laura Canetti, Elliot M. Berry, Yoel Elizur, Psychosocial predictors of weight loss and psychological adjustment following bariatric surgery and a weight-loss program: the mediating role of emotional eating. International Journal of Eating Disorders. ,vol. 42, pp. 109- 117 ,(2009) , 10.1002/EAT.20592
Marcia Levin Pelchat, Andrea Johnson, Robin Chan, Jeffrey Valdez, J Daniel Ragland, None, Images of desire: food-craving activation during fMRI. NeuroImage. ,vol. 23, pp. 1486- 1493 ,(2004) , 10.1016/J.NEUROIMAGE.2004.08.023
Mark Fineman, Shawn Flanagan, Kristin Taylor, Maria Aisporna, Larry Z. Shen, Kenneth F. Mace, Brandon Walsh, Michaela Diamant, Brenda Cirincione, Prajakti Kothare, Wen-I Li, Leigh MacConell, Pharmacokinetics and Pharmacodynamics of Exenatide Extended-Release After Single and Multiple Dosing Clinical Pharmacokinetics. ,vol. 50, pp. 65- 74 ,(2011) , 10.2165/11585880-000000000-00000