Functional objective parameters which may discriminate patients with mild cognitive impairment from cognitively healthy individuals: a systematic review and meta-analysis using an instrumented kinematic assessment

摘要: BACKGROUND a systematic review in 2015 showed kinematic gait and balance parameters which can discriminate patients with mild cognitive impairment (MCI) from cognitively healthy individuals. OBJECTIVE this meta-analysis aims to summarise synthesise the evidence published after previous about functional objective obtained by an instrumented assessment could MCI individuals, as well assess level of per outcome. METHODS major electronic databases were searched inception August 2019 for cross-sectional studies examining parameters, may Meta-analysis was carried out each parameter reported two or more studies. RESULTS Ten total 1,405 2,277 individuals included. Eight included low risk bias. Patients slower speed than Thus, single-task (d = -0.44, 95%CI [-0.60 -0.28]; P < 0.001), at fast pace (d = -0.48, [-0.72 -0.24]; P < 0.001) arithmetic dual-task (d = -1.20, [-2.12 P = 0.01) best discriminated both groups. CONCLUSION present shows Most bias, but grading recommendations assessment, development evaluation criteria