Evidence of genetic heterogeneity in the long QT syndrome

摘要: thee long QT syndrome (LQT) is a familial predisposition to sudden death from cardiac arrhythmias. M. Keating et al. performed linkage analysis in large Utah family and found that th disease was closely linked the Harvey ras-1 (H-ras-1) locus on chromosome 11. With use of probe pTBB-2 at H-ras-1 oncogene, logarithm likelihood ratio for (lod score) +16.44 obtained by In subsequent study, tight LQT six other small families. The combined lod score these two studies +21.65 recombination fraction 0. This suggests mutations or resulted families studied. view clinical heterogeneity possible genetic this syndrome, we analyzed Jewish with history LQT. family, whose origin island Jerba near Tunic members reside Israel, probably largest outside United States. It comprises 131 individuals, whom 28 have been affected. Clinical electrocardiographic data collected overmore » 7 years were available 92 blood samples 74. analysis, together al., provides evidence determination LQT.« less