Inflammatory Biomarkers are Correlated with Some Forms of Regressive Autism Spectrum Disorder.

摘要: Background: Several studies have tried to investigate the role of inflammatory biomarkers in Autism Spectrum Disorder (ASD), and their correlations with clinical phenotypes. Despite growing research this topic, existing data are mostly contradictory. Methods: Eighty-five ASD preschoolers were assessed for developmental level, adaptive functioning, gastrointestinal (GI), socio-communicative psychopathological symptoms. Plasma levels leptin, resistin, plasminogen activator inhibitor-1 (PAI-1), macrophage chemoattractant protein-1 (CCL2), tumor necrosis factor-alfa (TNF-α), interleukin-6 (IL-6) correlated scores compared among different subgroups according presence or absence of: (i) GI symptoms, (ii) regressive onset autism. Results: Proinflammatory cytokines (TNF-α, IL-6 CCL2) lower than those reported previous children systemic conditions. symptoms not except resistin that was ASD-GI (p = 0.032). Resistin PAI-1 significantly higher group “regression plus a delay” (Reg+DD group) groups without regression delay < 0.01 all). Conclusions: Our results did highlight any state subjects neither disentangling with/without The Reg + DD differed from others some plasmatic values, but these differences failed discriminate as possible distinct endo-phenotypes.