Biomedical Data Integration in Computational Drug Design and Bioinformatics

作者: Jose A. Seoane , Vanessa Aguiar-Pulido , Cristian R. Munteanu , Daniel Rivero , Juan R. Rabunal

DOI: 10.2174/15734099112089990010

关键词:

摘要: In recent years, in the post genomic era, more and data is being generated by biological high throughput technologies, such as proteomics transcriptomics. This omics can be very useful, but real challenge to analyze all this data, a whole, after integrating it. Biomedical integration enables making queries different, heterogeneous distributed biomedical sources. Data solutions useful not only context of drug design, also information retrieval, clinical diagnosis, system biology, etc. review, we most common approaches integration, federated databases, warehousing, multi-agent systems semantic technology, well developed using these past few years.

参考文章(106)
Julien Gobeill, Patrick Ruch, Emilie Pasche, Christel Daniel, Christian Lovis, Rémy Choquet, Douglas Teodoro, Biomedical data management: a proposal framework. medical informatics europe. ,vol. 150, pp. 175- 179 ,(2009)
Peter Tarczy-Hornoch, Joyce A. Mitchell, Peter Mork, Loren Donelson, M. Barrier, Hao Mei, Cindy Dolan, The BioMediator system as a data integration tool to answer diverse biologic queries. Studies in health technology and informatics. ,vol. 107, pp. 768- 772 ,(2004) , 10.3233/978-1-60750-949-3-768
Lee Feigenbaum, Ivan Herman, Tonya Hongsermeier, Eric Neumann, Susie Stephens, The Semantic Web in Action Scientific American. ,vol. 297, pp. 90- 97 ,(2007) , 10.1038/SCIENTIFICAMERICAN1207-90
Veli N. Stroetmann, Christian Lovis, Dirk Colaert, DebugIT for patient safety - improving the treatment with antibiotics through multimedia data mining of heterogeneous clinical data. medical informatics europe. ,vol. 136, pp. 641- 646 ,(2008)
N. Williams, How to get databases talking the same language. Science. ,vol. 275, pp. 301- 302 ,(1997) , 10.1126/SCIENCE.275.5298.301
Andrew Robinson, Wenny Rahayu, Genome Database Integration international conference on computational science and its applications. pp. 443- 453 ,(2004) , 10.1007/978-3-540-24767-8_46
Li Gong, Ryan P. Owen, Winston Gor, Russ B. Altman, Teri E. Klein, PharmGKB: an integrated resource of pharmacogenomic data and knowledge. Current protocols in human genetics. ,vol. 23, ,(2008) , 10.1002/0471250953.BI1407S23
Vadim Y. Bichutskiy, Rainer K. Brachmann, Richard H. Lathrop, Richard Colman, Heterogeneous biomedical database integration using a hybrid strategy: a p53 cancer research database. Cancer Informatics. ,vol. 2, pp. 277- 287 ,(2006) , 10.4137/CIN.S0
Patrick Lambrix, Lena Strömbäck, He Tan, Information Integration in Bioinformatics with Ontologies and Standards Semantic Techniques for the Web. ,vol. 5500, pp. 343- 376 ,(2009) , 10.1007/978-3-642-04581-3_8
P. Tarczy-Hornoch, A. Halevy, P. Mork, A model for data integration systems of biomedical data applied to online genetic databases. american medical informatics association annual symposium. pp. 473- 477 ,(2001)