Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury.

摘要: Hydrogen sulfide (H2S), known as an important cellular signaling molecule, plays critical roles in many physiological and/or pathological processes. Modulation of H2S levels could have tremendous therapeutic value. However, the study on has been hindered due to lack controllable releasing agents that mimic slow and moderate release vivo. In this work we report design, synthesis, biological evaluation a new class donors. Twenty-five donors were prepared tested. Their structures based perthiol template, which was suggested be involved biosynthesis. mechanism from these studied proved thiol-dependent. We also developed series cell-based assays access their H2S-related activities. H9c2 cardiac myocytes used experiments. tested lead donors’ cytotoxicity confirmed production cells. Finally demonstrated selected showed potent protective e...