Poorly differentiated small cell carcinoma of the pancreas. A case report and review of the literature.

作者: Simone Berkel , Frank Hummel , Jochen Gaa , Walter Back , Ralf Hofheinz

DOI: 10.1159/000080526

关键词:

摘要: Small cell carcinoma (SCC) of the pancreas is a rare malignancy with an extremely poor prognosis. We present case 74-year-old man 2-month history upper abdominal discomfort who was diagnosed SCC tail, involvement peripancreatic and mesenteric lymph nodes multiple liver metastases (extended disease). A CT scan positive somatostatin receptor scintigraphy showed no evidence primary lung tumour. The diagnosis confirmed by biopsy. Local tumour control could be achieved gemcitabine once week long-acting analogue month, but metastasis progress. Thus, 5-fluorouracil on weekly basis started. patient died 8 months after had not been hospitalised in meantime.

参考文章(45)
Raymond D. Hobbs, Andrew F. Stewart, Neil D. Ravin, Darryl Carter, Hypercalcemia in small cell carcinoma of the pancreas Cancer. ,vol. 53, pp. 1552- 1554 ,(1984) , 10.1002/1097-0142(19840401)53:7<1552::AID-CNCR2820530722>3.0.CO;2-S
R. Chetty, S.P. Clark, G.A. Pitson, Primary Small Cell Carcinoma of the Pancreas Pathology. ,vol. 25, pp. 240- 242 ,(1993) , 10.3109/00313029309066580
Francis P Worden, Gregory P Kalemkerian, Therapeutic advances in small cell lung cancer. Expert Opinion on Investigational Drugs. ,vol. 9, pp. 565- 579 ,(2000) , 10.1517/13543784.9.3.565
Koichi Motojima, Junichiro Furui, Masazumi Terada, Toshiaki Shiogama, Norihiro Kohara, Tsukasa Tsunoda, Ryoichi Tsuchiya, Small cell carcinoma of the pancreas and biliary tract Journal of Surgical Oncology. ,vol. 45, pp. 164- 168 ,(1990) , 10.1002/JSO.2930450306
C.C. Earle, D.J. Stewart, Y. Cormier, W.K. Evans, S.Z. Gertler, C. Mihalcioiu, P.D. Walde, A phase I study of gemcitabine/cisplatin/etoposide in the treatment of small-cell lung cancer. Lung Cancer. ,vol. 22, pp. 235- 241 ,(1998) , 10.1016/S0169-5002(98)00085-3
Timothy P. O'Connor, Terence P. Wade, Young C. Sunwoo, Hans-Joachim Reimers, Diane C. Palmer, Alan B. Silverberg, Frank E. Johnson, Small cell undifferentiated carcinoma of the pancreas. Report of a patient with tumor marker studies Cancer. ,vol. 70, pp. 1514- 1519 ,(1992) , 10.1002/1097-0142(19920915)70:6<1514::AID-CNCR2820700612>3.0.CO;2-C